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Measuring the Masses to Derive Biological Knowledge: How to Apply LC and MS Data to Annotate Metabolites in Untargeted Metabolomic Studies

July 20 @ 11:30 am - 12:00 pm

Title: Measuring the Masses to Derive Biological Knowledge: How to Apply LC and MS Data to Annotate Metabolites in Untargeted Metabolomic Studies

Date: Tuesday, July 20, 2021

Time: 11:30 AM Eastern Daylight Time

Duration: 1 hour, 30 minutes

Measuring the Masses to Derive Biological Knowledge: How to Apply LC and MS Data to Annotate Metabolites in Untargeted Metabolomic Studies

Untargeted metabolomic UHPLC-MS assays acquire large volumes of high-quality data for thousands of metabolites in biological samples in an automated and medium-to-high throughput workflow. The conversion of these data in to biological knowledge requires each signal to be matched to a metabolite, a process called metabolite annotation or identification and which uses chromatographic retention time, MS1 and MS/MS data. In this presentation we will discuss the analytical and computational workflows applied to annotate metabolites, the tools applied to aid the workflow and the databases and libraries which are available. Key tips and tricks will also be discussed.

Prof. Warwick (Rick) Dunn
Prof. Warwick (Rick) Dunn
Professor of Analytical and Clinical Metabolomics
School of Biosciences and Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

Professor Warwick (Rick) Dunn holds a chair in Analytical and Clinical Metabolomics at the University of Birmingham. He graduated from the University of Hull with a BSc (Hons) degree and Ph.D. in Analytical Chemistry and Toxicology. After his Ph.D. he worked in a number of analytical chemistry roles in industry and academia before moving to the University of Manchester in 2003 to work as a post-doctoral researcher focused on metabolomics in the group of Professor Douglas Kell and subsequently in the group of Professor Roy Goodacre. Rick obtained a lectureship in 2011 at the University of Manchester and moved to a lectureship at the University of Birmingham in 2013. He is passionate about teaching the next generation of metabolomics and metabolism researchers through undergraduate and postgraduate degrees at the University of Birmingham and as Director of the Birmingham Metabolomics Training Centre. His research includes analytical chemistry developments to apply in untargeted and targeted metabolomic studies, with a large emphasis on metabolite annotation, as well as the study of metabolism in human health, diseases and ageing to develop new precision medicine tools. Further information is available at https://more.bham.ac.uk/bamcg/.

Organizer

Metabolomics Consortium Coordinating Center (M3C)
Email:
info@metabolomics.info
Website:
metabolomics.info