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MANA Summer Symposium

September 10 @ 9:00 am - 2:30 pm

Venue: Online, 9:00 AM – 2:30 PM PST, MANA

Overview: Untargeted metabolomics and lipidomics data provide exciting prospects for defining biological mechanisms and finding novel hypotheses and disease associations. Current workflows mostly rely on accurate precursor masses and matching experimental to library MS/MS spectra. However, False Discovery Rates (FDR) for this classic method remain poorly studied. FDRs may possibly be much larger than anticipated due to multiple adduct species, (relative) retention time exclusions, and in-source fragmentations. This symposium will discuss how LC-MS/MS annotations can achieve increased confidence by using complementary information from ion mobility (CCS). We will also evaluate how many isomeric compounds should be considered given background information from chemical and biochemical databases and atlases, genetic inferences and biological literature data on species, organs and cells.

The symposium starts at 9 AM PST.

Additional information here.