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Challenges in Analysis of Complex Natural Mixtures Faraday Discussion
May 13 - May 15
Structure determination of molecules contained within unresolved complex mixtures represents an unsolved question that continues to challenge physical and analytical chemistry. Most naturally occurring systems can be characterised as complex mixtures. These can be broadly divided according to the molecular sizes of their constituents, into mixtures of small or large molecules. The focus of this Faraday Discussion will be on the former, while the latter such as biomacromolecules, industrial polymers, or solid matrices are outside of its scope as such. Nevertheless, the processes that are used in analysing the data originating from these studies may be of interest.
Examples of small molecule mixtures include:
- Environmental matrices such as soil, dissolved organic matter, organic molecules contained in atmospheric aerosol particles, or crude oil
- Man-made mixtures of small molecules such as food, beverages or plant extracts
These systems are generally classed as “complex mixtures” or “unresolved complex mixtures (UCM)”, emphasising our current inability to separate their individual components. The techniques best positioned to tackle such mixtures experimentally include mass spectrometry, chromatography, NMR spectroscopy, or new alternative techniques, including combinations of the above methods. For the most part, people who work on the analysis of complex mixtures are driving the progress in exploiting new methodologies and their creative combinations.